Energy metabolism in heart failure
نویسندگان
چکیده
منابع مشابه
Exercise training has restorative potential on myocardial energy metabolism in rats with chronic heart failure
Objective(s): Exercise training is a well-known accelerator for the treatment of chronic heart failure (CHF). The current study aimed to investigate the restorative effects of aerobic interval training (AIT) intervention on myocardial energy metabolism in CHF rats. Materials and Methods: Post-myocardial infarction (MI) heart failure animal model was established. The Sprague-Dawley rats were ran...
متن کاملEnergy metabolism in heart failure and remodelling.
Myocytes of the failing heart undergo impressive metabolic remodelling. The time line for changes in the pathways for ATP synthesis in compensated hypertrophy is: flux through the creatine kinase (CK) reaction falls as both creatine concentration ([Cr]) and CK activity fall; increases in [ADP] and [AMP] lead to increases in glucose uptake and utilization; fatty acid oxidation either remains the...
متن کاملExercise training, energy metabolism, and heart failure.
Energy metabolism is at the crossroad of cell function and dysfunction. Cardiac and skeletal muscle cells, the energy metabolism of which is high, fluctuating, and adaptable to the special needs of the body, have developed sophisticated strategies for synthesizing, transferring, and utilizing energy in accordance with the needs of the body. Adaptation to endurance training mainly involves energ...
متن کاملEnergy metabolism of the completely isolated mammalian heart in failure.
Experimental cardiac failure was reinvestigated in tlie completely isolated mammalian heart using a simplified system in which only the left ventricle performs work and exhibits volume changes. An effort was made to assess the importance of such experimental artefacts as acapnia, altered or depleted substrate, and controlled (constant) diastolic volume. None of these factors appeared to play a ...
متن کاملMitochondrial energy metabolism in heart failure: a question of balance.
The mitochondrion serves a critical role as a platform for energy transduction, signaling, and cell death pathways relevant to common diseases of the myocardium such as heart failure. This review focuses on the molecular regulatory events and downstream effector pathways involved in mitochondrial energy metabolic derangements known to occur during the development of heart failure.
متن کاملذخیره در منابع من
با ذخیره ی این منبع در منابع من، دسترسی به آن را برای استفاده های بعدی آسان تر کنید
ژورنال
عنوان ژورنال: The Journal of Physiology
سال: 2004
ISSN: 0022-3751
DOI: 10.1113/jphysiol.2003.055095